Lab size – is bigger always better?

A ton of blog posts and a few papers have been written on the issue of the optimal size of a biomedical research lab. If you would like a nice digest, see this Youtube video by Jon Lorsch, the director of one of the NIH institutes. Jon makes a very good case for smaller labs. They allow for more diversity, better mentoring, are more efficient with their use of funds. Unfortunately, almost all incentives in academia are for group leaders to have bigger labs. The PI of  a larger group has more security in terms of funding and employment, more prestige, more negotiating power in almost any situation. Almost no one in academia looks at how efficient in terms of output per dollar a group is – they invariably look at the total output of the lab, ie. the total number/prestige/citations of pubs where the PI is senior author. Similarly, no one looks at how well the PI’s trainees do on average – they only look at the few superstars that have come out of the lab.
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